2024年12月11日，华中农业大学李斌教授团队梁宏闪副教授课题组在国际食品Top期刊《Journal of Agricultural and Food Chemistry》（Q1，IF=5.7）发表题为“Citrus Polymethoxyflavones Regulate against Aging-Associated Diseases: Advances in Biological Mechanisms Responsible for Their Regulation”的综述论文，2024年12月25日被选为封面论文。
成果介绍
1. 随着全球老龄化人口比例逐年上升，与年龄相关的疾病，包括神经退行性疾病、代谢性疾病和心血管疾病，最近引起了食品科学家和营养学家的广泛关注。
2. 多甲氧基黄酮（PMFs）是膳食类黄酮的一种，因其具有多种生物活性，包括抗氧化、抗炎、神经保护和代谢调节作用，已成为潜在的抗衰老候选物质。本综述总结并讨论了PMFs对衰老的影响，详细阐述了PMFs介导的调节作用与预防或治疗各种衰老相关疾病的可能机制。此外，还从 PMFs 在体内的吸收、分布、代谢和排泄等方面详细讨论了 PMFs 的生物学归宿。特别关注了 PMF 的生物利用率与生物活性之间的关系，因为 PMF 的生物利用率低会严重影响其生物活性。
3. 总之，所有这些结论都有助于为进一步研究 PMF 对衰老的影响提供一个视角。
图文赏析
TOC
Figure 1. Classification and chemical structures of citrus flavonoids, including representative compounds of commonly studied citrus polymethoxyflavones (PMFs).
Figure 2. (A) Schematic diagram of free radical theory in aging (upper) and summary of related cellular mechanisms and pathways over prevention from oxidative stress (lower), including structure–activity links of PMFs on their diverse antioxidant activities. (B) Potential anti-inflammatory signaling pathways and mechanisms of citrus PMFs.
Figure 3. (A) Schematic representation partially of the age-related diseases described grouped by organs or systems. (B) Neuroprotective effects of PMFs and related molecular mechanisms by inhibiting the activities of BACE1, promoting CREB phosphorylated levels and ChAT gene transcription, enhancing the level of ACh and the activity of nAChR.
Figure 4. Potential molecular mechanisms of metabolic syndrome regulatory effects of PMFs by lowering lipid effect and modulating gut homeostasis.
Figure 5. Schematic illustration of the identified targets that facilitate the anticardiovascular effects.
Figure 6. Role of PMFs in two major signaling pathways inducing bone formation (A,B) and inhibiting osteoclast activity (blocking RANKL synthesis) (C).
