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  • 吕优优
  • 系所

    食品科学与工程系
  • 职称

    讲师
  • email

    lvyouyou@mail.hzau.edu.cn、youyoulv666@163.com
  • 硕/博导

  • 讲授课程

    拟讲授乳品工艺学、食品工程原理等课程

个人简介

吕优优,中共党员,男,博士。2021年6月获中国海洋大学食品科学专业学术型博士学位,2021年12月就职于华中农业大学食品科学技术学院。研究方向为功能性乳品与益生乳酸菌工程,熟悉并掌握酸奶等乳制品加工技术、益生菌高密度培养及其应用技术,擅长斑马鱼、小鼠等动物实验。博士期间作为骨干参与2项国家科技部重大专项。就读期间共计发表研究论文23篇,包括20篇SCI,其中一作(含共一)SCI为7篇。申请专利8项,其中导师一作,本人二作为3项,已公布3项。参编专著2部,其中《肿瘤微生态学》现已出版。博士期间荣获“山东省高等学校科学技术一等奖”1次。

教育经历

2017.9–2021.6, 中国海洋大学, 食品科学, 博士
2015.9–2017.6, 西北农林科技大学, 生物工程, 硕士
2011.9–2015.6, 河南工业大学, 食品科学与工程, 学士

工作经历

2021.12-至今, 华中农业大学, 食品科学技术学院, 讲师

研究领域

益生乳酸菌资源开发,功能性乳品与益生乳酸菌工程

科研项目

(1)中华人民共和国科技部,“乳酸菌或蛋白酶水解生产特定功能乳制品产品研究与应用示范”,2018YFC1604302,2018-12至2021-12,在研,骨干。
(2)中华人民共和国科技部,“恶性肿瘤姑息治疗和护理关键技术研究”,ZDZX2017ZL-03-02,2017-07至2020-12,结题,骨干。

成果奖励

发表论文
1. Youyou Lu, Junxue Zhang, Huaxi Yi, Zhe Zhang, Lanwei Zhang*. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model. Food & Function, 2019, 10(4):2075-2082
2. Youyou Lu, Zhe Zhang, Xi Liang, Yujie Chen, Junxue Zhang, Huaxi Yi, Tongjie Liu, Liuqing Yang, Hanping Shi*, Lanwei Zhang*. Study of gastrointestinal tract viability and motility via modulation of serotonin in a zebrafish model by probiotics. Food & Function, 2019, 10(11):7416-7425
3. Youyou Lu, Zhuang Yu, Zhe Zhang, Xi Liang, Pimin Gong, Huaxi Yi, Liuqing Yang, Tongjie Liu, Hanping Shi*, Lanwei Zhang*. Bifidobacterium animalis F1-7 in combination with konjac glucomannan improves constipation in mice via humoral transport. Food & Function, 2021, 12(2):791-801
4. Youyou Lu, Zhe Zhang, Lingjun Tong, Xiaohong Zhou, Xi Liang, Huaxi Yi1, Pimin Gong, Tongjie Liu, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Mechanisms underlying the promotion of 5-hydroxytryptamine secretion in enterochromaffin cells of constipation mice by Bifidobacterium and Lactobacillus. Neurogastroenterology and Motility, 2021, 33:e14082
5. Youyou Lu#, Junxue Zhang#, Xiaohong Zhou, Meiyu Guan, Zhe Zhang, Xi Liang, Lingjun Tong, Huaxi Yi, Pimin Gong, Lu Bai, Hui Zhou, Tongjie Liu*, Lanwei Zhang*. The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish. Neurogastroenterology and Motility, 2021, 33:e14196
6. Youyou Lu#, Junxue Zhang#, Zhe Zhang, Xi Liang, Tongjie Liu, Huaxi Yi, Pimin Gong, Lingli Wang, Wenjun Yang, Xinyi Zhang, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release. Nutrition, 2021, 84:111112
7. Youyou Lu, Nana Wang, Jiao He, Yanfang Li, Xiaoning Gao, Lili Huang*, Xia Yan*.Expression and characterization of a novel chitinase with antifungal activity from a rare actinomycete, Saccharothrix yanglingensis Hhs.015. Protein Expression and Purification, 2018, 143:45-51
8. Xi Liang, Youyou Lv, Zhe Zhang, Huaxi Yi, Tongjie Liu, Rui Li, Zhuang Yu, Lanwei Zhang*. Study on intestinal survival and cholesterol metabolism of probiotics. LWT-Food Science and Technology, 2020, 124: 109132
9. Xi Liang, Zhe Zhang, Youyou Lv, Haiyan Lu, Tongjie Liu, Huaxi Yi, Maozhen Zhao, Lanwei Zhang *,Pimin Gong*. Krill oil combined with Bifidobacterium animalis subsp. lactis F1-7 alleviates the atherosclerosis of ApoE-/- mice. Foods, 2021, 10, 2374
10. Zhe Zhang, Xi Liang, Youyou Lv, Huaxi Yi, Yujie Chen, Lu Bai, Hui Zhou, Tongjie Liu, Rui Li, Lanwei Zhang*. Evaluation of probiotics for improving and regulation metabolism relevant to type 2 diabetes in vitro. Journal of Functional Foods, 2020, 64:103664
11. Xi Liang, Zhe Zhang, Youyou Lv, Linjun Tong, Tongjie Liu, Huaxi Yi, Xiaohong Zhou, Zhuang Yu, Xiaoying Tian, Qingyu Cui, Jiebing Yang, Pimin Gong, Lanwei Zhang*. Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis. Nutrition, 2020, 79:110941
12. Yeting Wu, Hong Lin, Youyou Lu, Yuhao Huang, Binaka Prabashini Dasanayaka, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL-2H3 cell and mouse model. European Food Research and Technology, 2021,1-16
13. Lingjun Tong, Haining Hao, Zhe Zhang, Youyou Lv, Xi Liang, Qiqi Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Fangfang Cao, Giorgia Pastorin, Chuen Neng Lee, Xiaoyuan Chen, Jiong-Wei Wang*, Huaxi Yi*. Milk-derived extracellular vesicles alleviate ulcerative colitis byregulating the gut immunity and reshaping the gut microbiota. Theranostics, 2021, 11(17): 8570-8586
14. Zhe Zhang, Xi Liang, Lingjun Tong, Youyou Lv, Huaxi Yi, Pimin Gong, XiaoyingTian, Qingyu Cui, Tongjie Liua*, Lanwei Zhang*. Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice. Journal of Ethnopharmacology, 2021, 273:113963
15. Xi Liang, Zhe Zhang, Xiaohong Zhou, Youyou Lu, Rui Li, Zhuang Yu, Lingjun Tong, Pimin Gong, Huaxi Yi, Tongjie Liu*, Lanwei Zhang*. Probiotics improved hyperlipidemia in mice induced by a high cholesterol diet via downregulating FXR. Food & Function, 2020, 11(11):9903-9911
16. Zhe Zhang, Hui Zhou, Lu Bai, Youyou Lv, Huaxi Yi, Lanwei Zhang*, Rui Li*. Protective effects of probiotics on acute alcohol-induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-α response reduction. Journal of Functional Foods, 2019, 59:234-241
17. Lingjun Tong, Haining Hao, Xinyi Zhang, Zhe Zhang, Youyou Lv, Lanwei Zhang, Huaxi Yi*. Oral Administration of Bovine Milk-derived Extracellular Vesicles Alters the Gut Microbiota and Enhances Intestinal Immunity in Mice. Molecular Nutrition & Food Research, 2020, 64(8):1901251
18. Zhe Zhang#, Hui Zhou#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in mice. British Journal of Nutrition, 2020, 28:1-11
19. Zhe Zhang#, Hui Zhou#, Xiaohong Zhou, Jize Sun, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 ameliorates markers of non-alcoholic fatty liver and alters expression of genes within the intestinal bile acid pathway. British Journal of Nutrition, 2021, 125(5):521-529
20. Zhe Zhang#, Lu Bai#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Huaxi Yi, Hui Zhou, Tongjie Liu*, Pimin Gong, Jize Sun*, Lanwei Zhang*. Potential probiotics Lactobacillus casei K11 combined with plant extracts reduce markers of type 2 diabetes mellitus in mice. Journal of Applied Microbiology, 2021, 131, 1970-1982
21. 白璐,张喆,梁曦,吕优优,周慧,张峻雪,易华西,刘同杰,公丕民,冯丽荣,冷友斌*,张兰威*. 益生菌对2型糖尿病小鼠的调节作用.食品工业科技, 2020,41(19):339-346.
22. 杨文君,刘同杰,梁曦,张喆,崔庆宇,吕优优,公丕民,易华西,章检明,刘大群,张兰威*.2’-岩藻基乳糖对益生菌定殖及抗炎能力的影响.食品工业科技,2021,42(20):355−364.
23. 赵茂臻,梁曦,张喆,吕优优,王引,刘同杰,易华西,公丕民,张兰威*.植物乳杆菌F3-2联合甘露低聚糖通过上调SCFAs抑制PPARγ改善小鼠肥胖. 食品工业科技,https://doi.org/10.13995/j.cnki.11-1802/ts.027495.
申报专利
1. 公丕民,吕优优,张兰威,刘同杰,易华西,张喆,梁曦。一株副干酪乳杆菌X11及其组合物便秘复合制剂及乳制品。(公布号CN 112694989 A)
2. 张兰威,吕优优,公丕民,刘同杰,易华西,张喆,梁曦。一株动物双歧杆菌F1-7、组合物、粪便干结复合制剂及果乳制品。(公布号CN 113186113 A)
3. 张兰威,吕优优,公丕民,刘同杰,易华西,张喆,梁曦。一株促肠蠕动动物双歧杆菌亚种F1-7及应用。(公布号CN 113564067 A)
4. 刘同杰,梁曦,张兰威,张喆,吕优优,易华西,公丕民。一种改善动脉粥样硬化脂质代谢动物双歧杆菌F1-7和磷虾油组合物制备方法及应用。(公布号CN 113349375 A)
5. 张兰威,梁曦,公丕民,易华西,刘同杰,吕优优,张喆。一种改善动脉粥样硬化炎症的动物双歧杆菌F1-7和磷虾油组合物制备方法及应用。(公布号CN 112690456 A)
6. 公丕民,张喆,张兰威,易华西,刘同杰,梁曦,吕优优。一种干酪乳杆菌K11与苦瓜皂苷降血糖组合物制备方法及应用。(公布号CN 112641810 A)
7. 张兰威,张喆,梁曦,易华西,公丕民,刘同杰,吕优优。一种降糖和改善脂质紊乱桦树茸提取物制备方法及应用。(公布号CN 112494523 A)
8. 张兰威,张喆,刘同杰,易华西,公丕民,梁曦,吕优优。一种降糖植物乳杆菌YZX21功效及应用。(公布号 CN 112852662 A)
参编与出版专著
《肿瘤微生态学》/石汉平等主编.北京:科学出版社,2021.6 ISBN 9787030691347
荣誉奖励
1. “第十六届益生菌与健康国际研讨会优秀论文奖”,2021;
2. “中国海洋大学食品科学与工程学院模范共产党员”,2021
3. 吕优优(8/10),益生乳酸菌定向筛选及其高活性产品开发的关键技术,“山东省 高等学校科学技术奖一等奖”,2020;
4. “中国海洋大学食品科学与工程学院硕博研究生学术论坛口头汇报一等奖”,2019;
5. “中国海洋大学优秀博士研究生”,2018;
6. “西北农林科技大学生命科学学院优秀毕业生”,2017;
7. “河南省省级优秀毕业生” “校级优秀毕业论文”,2015;
8. “国家励志奖学金”,2012
学术兼职
受邀作为Food & Function和Journal of Clinical Microbiology and Biochemical Technology等期刊审稿人。

其它

1. 主持“西北农林科技大学旱区作物逆境生物学国家重点实验室第三届研究生学术论坛”
2. 主持“中国海洋大学食品科学与工程学院2019年硕博研究生学术论坛博士专场”
3. 2018-2020年担任“中国海洋大学食品科学与工程学院功能性乳品与益生菌工程实验室主任助理”,全面负责协助导师实验室管理事宜

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